ARC: AAA ATPase forming Ring-shaped Complexes

- An AAA family with a very narrow host spectrum

ARC proteins have been found only in Actinomycetales (Streptomyces, Rhodococcus, Mycobacterium). The host organisms are also the only eubacteria containing a 20 S proteasome, the corresponding genes are close to the respective ARC gene.The whole gene cluster has probably been acquired by a horizontal gene transfer. It is tempting to speculate that the ARCs originated from a proteasomal AAA cap subunit, and maybe still perform that function. ARCs are currently the only known eubacterial AAA members not belonging to the Zn-protease subfamily (ftsH, YME1). ARC proteins contain an N-terminal coiled coil domain.

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Last edited: August 10, 1999 by KaiFr