HSLU

• Source: Escherichia coli
• Synonyms:
• Length: 443 aa residues
• Subfamily: Far relative
• Database entries:
  • embl:ECUW87 L19201 PID:g305034
  • swissprot:HSLU_ECOLI P32168
  • pir2:JT0761 JT0761
  • pir2:S40874 S40874
• Functions/properties:
  • Heat shock protein (belongs to the ClpX subfamily of chaperones)
  • Similarity to AAA family limited to ATP binding consensus
  • HslU is part of a two-component protease complex (HslUV) related to the proteasome with HslV corresponding to the 20S proteasome core and ATPase HslU and ATP stimulating the proteolytic activity
  • HslUV form cylindrical four-ring structures in which the HsIV dodecamer is flanked at each end by a HslU ring
• References:
  • Kaneko T, Sato S, Kotani H, Tanaka A, Asamizu E, Nakamura Y, Miyajima N, Hirosawa M, Sugiura M, Sasamoto S, Kimura T, Hosouchi T, Matsuno A, Muraki A, Nakazaki N, Naruo K, Okumura S, Shimpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Tabata S; Nucleic Acids Res. 21, 3391-3398 (1993) Medline: 97061201
  • Chuang SE, Burland V, Plunkett III G, Daniels DL, Blattner FR; Gene 134, 1-6 (1993) Medline: 94063501
  • Neuwald AF, Berg DE, Stauffer GV; Proc. Natl. Acad. Sci. USA 93, 5808-5813 (1996) Medline: 93013006
  • Haracska L, Udvardy A; Nat. Struct. Biol. 4, 133-139 (1997) Medline: 96176974

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