AAA Proteins involved in Centrosome Function and ER Homotypic Fusion.

The family is characterized by the presence of two well conserved copies of the AAA region and an overall high conservation during evolution (with 70% identical residues between S. cerevisiae CDC48p and the vertebrate orthologues and 43% identity to the archaebacterial homologues over the full lengths of the proteins). The family branches into 5 subfamilies.
Most is known about the subfamily containing CDC48 and VCP/p97, its members participate in the homotypic fusion of ER and Golgi membranes and have a role in or following polyubiquitination.
One subfamily contains the archebacterial members of the family. The high conservation between especially the archebacterial and the CDC48 branch is puzzling, as the functions of the CDC48 orthologues appear to make no sense in archebacteria, which contain neither ER, a Golgi apparatus, nor ubiquitin.
The other three branches contain AFG2/DRG1 (drg1 confers diazaborine resistance), YTA7, and smallminded which is necessary for the correct development of the central nervous system in Drosophila larvae, respectively .

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Last edited: August 10, 1999 by KaiFr