AAA Members Involved in Meiosis, Microtubule Severing, and in Mitochondrial Functions

These proteins, containing a single AAA motif, form the least defined cluster in the tree, and divergent functions have been reported: for mei-1 a role in meiotic spindle function, for katanin a microtubule severing activity, for MSP1 a role in intramitochondrial sorting resembling the mitochondrial members of the metalloprotease family. The increasing number of sequences and additional information about function may result in a subdivision of the family in the future.
The family appears not to be restricted to eukaryotes: some -but definitely not all- archebacteria contain AAA genes/proteins with a single AAA motiv and high similarity to members of this family.

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Last edited: August 10, 1999 by KaiFr