Metalloproteases in Eubacteria, Mitochondria and Chloroplasts

Members of this family have been found in all eubactera and their endosymbiotic descendants, mitochondria and chloroplasts. This is the only family of the AAA superfamily with known eubacterial members - exept for the ARC family found only in Actimomycetales. Its members are characterized by a single conserved AAA module, an amino terminal transmembrane domain, and a Zn-dependent protease motive. Their bacterial members degrade transcriptional regulators (phage lambda cII protein and sigma(32), the transcriptional regulator of heat shock response). Mutations of the mitochondrial members cause multiple mitochondrial defects. Besides proteolytic functions, a role as chaperones in the assembly of protein complexes has been postulated.

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Last edited: August 10, 1999 by KaiFr